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Sources:The
root of Fagopyrum dibotrys (D.Don) Hara Family Polygonaceae.
Constituents:Containing
hydroxy-anthraquinones, shakuchirin, shaouch- trin, glycosides,b-sitosterol,
tannin, etc.
Actions: Studies
in vitro showed that the tannin compound Ji-E has an inhibitory
action against GLC,Hela, SGC and KB cell lines, the IC50 were
67.8, 73.1, 79.9, and 9.83¦Ìg/ml, respectively.
Experiments in vivo proved that the water extract of the herb
at the dose of 20g/kg was taken once daily for continued 10
days, on LLC and U14, the inhibitory rates were 36.4%~40.7%
and 30.97%~53.24% respectively.
Indications:The
response of human lung cancer explants to extracts E and CD1
of Rhizoma Fagopyri Cymosi was determined by subrenal capsule
(SRCA)assay. A total of 12 lung cancers were tested in which
60 xenografts were implanted, with a mean tumor growth >5
OMU (1 OMU=0.02mm) in the control animals the assdy was considered
evaluable. The trials provided an evaluable assay rate of
83.8%. Taking<-10 OMU of tumor xenograft size as standard
of response, the extracts Ji-E and CD1 offered response rates
of 40% and 20% respectively. Squamous cell carcinoma was more
sensitive to Ji-E than other type of lung carcinoma. These
findings were similar to the clinical effects of CD1 in phase-I
trials. SRC assay might be of value in prediction human tumor
response to new anticancer drugs prior to clinical phase-I
trials.
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