|
Sources:The
fruits, roots, branches and leaves of Camptotheca acuminata
Decne. Family Nyssaceae.
Constituents:Containing
camptothecine,10-hydroxy-camptothecine, meth- oxycamptothecine,
etc.
Actions:CPT and
HCPT were the effective anticancer principles of the herb.
CPT at dose 10~12mg/kg ip. was effective against L615, S180,
EAC, P388, and L1210, HCPT at 1~2mg/kg*10, ip. was effective
against EAC, HepA, ARS, YAS, S180, S37, U14 and W256 murine
tumors. HCPT at 2.5mg/kg*5, ip. was effective against human
tumors (subrenal capsule tumor inoculation of lung squamous
cancer and liver cancer), the inhibiting rates were 37.3%
and 44.3% (P<0.01) respectively. CPT and its derivativ-
es have activity on TOPO I, CPT at 144umol/L and HCPT at 69
umol/L both have significant activity on TOPO I.
Indications:CPT
amp preparation at dose of 5~10mg/a day with intravenous injection,
one course of treatment was 140mg,951 cases of various kinds
of cancers were treated, the results showed that 435 cases
of gastric cancer, PR 70, MR 195, NC 170 cases; 47 cases of
intestine cancer, PR 5, MR 18, NC 24; 40 cases of leukemias.
HCPT has been used for treatment of
more than 200 cases of gastric liver, head and neck cancers
and leukemias, the total effective rate was 44%, the toxicity
was smaller than that of CPT.
The emulsion ointment of the herb (made
by the fruit extrat powder and vaseline) externally used for
treatment of 77 cases of skin cancers, PR 61%, MR 87% were
obtained.
The protein microsphere of CPT was used
for treatment of liver cancer, it was played a role as a chemotherapeutic
embolism action.
The derivatives of CPT (CPT-11) made
in Japan, in phase II clinical trial was proved to have anticancer
effect against small cell lung cancer. The 9-aminocamptothecine
made in U.S.A has similar anticancer action.
|
