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Sources:The
whole of Blatta orientalis Linnaeus Family Blattidae.
Constituents:Containingscleerotin,chitin,wax,shellac,proteinase,amylase, lipase and maltase,etc.
Actions:The AT-2
extracted from the insect was effective against S180 and S37
tumors on mouse, the inhibiting rates were 44%~52% and 34%~42.7%
respectively. The oil extracted from the insect ip. 0.4g/kg¡Á10d,the
inhibiting rate against S180 was 39%~45%,sc.0.1ml/10g was
effective against human esophageal carcinoma (renal subcapsular
tumor inoculation method),the effect was similar to 0.025g/kg
of 5-FU.
Indications:
In clinic, AT-2 was used to treat median stage and advanced
liver cancer patients.The 49 cases were compared with 46 cases
(treated with chemotherapy and Chinese medicine) as control
group. AT-2 was administered with 6~8 tabs t.i.d. for one
month. The results showed that in AT-2 group,PR rate was 2%,
median period of PR was 6.6 months,stable rate was 55.1%.
The average life span in TA-2 group was
9.75 months, the half and one year survival rates were 31.9%
and 14.9%; in control group, were 7.03 months and 8.7%, 0%
respectively. The differences between the two groups (P<0.05)
were significant. The symptoms improvement in TA-2 group were
better than that of control group, such as, the alleviation
of pain liver area, the improvement of fatingue and the reduction
of hepatomegaly.In TA-2 group, the AFP test showed that its
AFP turning negative or decreasing rates were 23.5%,but in
control group was 0%,in AT-2 group, the platelets,WBC and
lymphocyte blastogenesis were increased,as well.
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